Investigation of the Relationship of Some Antihypertensive Drugs with Oxidant/Antioxidant Parameters and DNA Damage on Rat Uterus Tissue

Salman S., Kumbasar S., GÜRSAN N., KUMTEPE Y., BÖREKÇİ B., Polat B., ...Daha Fazla

INTERNATIONAL JOURNAL OF FERTILITY & STERILITY, cilt.5, sa.2, ss.96-103, 2011 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 2
  • Basım Tarihi: 2011
  • Dergi Adı: INTERNATIONAL JOURNAL OF FERTILITY & STERILITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-103
  • Anahtar Kelimeler: Antihypertensive, Oxidant/Antioxidant Parameters, DNA Damage, GASTRIC-MUCOSAL INJURY, LIPID-PEROXIDATION, OXIDATIVE STRESS, FREE-RADICALS, MECHANISM, ANTIOXIDANTS, 8-OXOGUANINE, GLUTATHIONE, ESTROGEN, DISEASE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically.