ASIAN JOURNAL OF ORGANIC CHEMISTRY, cilt.10, sa.7, ss.1814-1821, 2021 (SCI-Expanded)
Metal- and additive-free C3-alkylation of imidazo[1,2-a]pyridines with para-quinone methides (p-QMs) has been realized. 1,6-Nucleophilic addition of imidazopyridines to p-QMs were carried out under mild conditions in very excellent yields. Furthermore, we performed late-stage drug functionalization for zolimidine. All transformations proceeded with broad substrate scope and good functional group tolerance.