Metal- and Additive-Free C3-Functionalization of Imidazo[1,2-a]pyridines with para-Quinone Methides
ASIAN JOURNAL OF ORGANIC CHEMISTRY, cilt.10, sa.7, ss.1814-1821, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 7
- Basım Tarihi: 2021
- Doi Numarası: 10.1002/ajoc.202100313
- Dergi Adı: ASIAN JOURNAL OF ORGANIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, Chemical Abstracts Core, Index Chemicus (IC), Current Chemical Reactions (CCR)
- Sayfa Sayıları: ss.1814-1821
- Anahtar Kelimeler: Imidazo[1, 2-a]pyridine, HFIP, para-quinone methide, zolimidine, 1, 6-nucleophilic addition, 1,6-CONJUGATE ADDITION, CATALYST, EFFICIENT, ACCESS
- Atatürk Üniversitesi Adresli: Evet
Özet
Metal- and additive-free C3-alkylation of imidazo[1,2-a]pyridines with para-quinone methides (p-QMs) has been realized. 1,6-Nucleophilic addition of imidazopyridines to p-QMs were carried out under mild conditions in very excellent yields. Furthermore, we performed late-stage drug functionalization for zolimidine. All transformations proceeded with broad substrate scope and good functional group tolerance.