The Nanosuspension Formulations of Daidzein: Preparation and In Vitro Characterization

UĞUR KAPLAN A. B., ÖZTÜRK N., ÇETİN M., VURAL İ., ÖZNÜLÜER ÖZER T.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.19, sa.1, ss.84-92, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/tjps.galenos.2021.81905
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.84-92
  • Anahtar Kelimeler: Cytotoxicity, daidzein, FTIR analysis, nanosuspension, media milling, PLGA NANOPARTICLES, DOSAGE FORMS, NANOEMULSIONS, ENHANCEMENT
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objectives: Daidzein (DZ), a water-insoluble isoflavone, has many beneficial effects (anti-inflammatory, antioxidant, and anticancer effects, etc.) on human health. DZ has a very low oral bioavailability related to its physicochemical properties (low solubility, intense metabolism of DZ in the intestine and liver). This study aimed to prepare and in vitro characterize the nanosuspension formulations of DZ to improve the poor solubility and efficacy of DZ.