Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

Creative Commons License

Sevim Ç., AKPINAR E., Aksu E. H., ÖMÜR A. D., YILDIRIM S., KARA M., ...Daha Fazla

Toxics, cilt.11, sa.2, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.3390/toxics11020170
  • Dergi Adı: Toxics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Pollution Abstracts, Directory of Open Access Journals
  • Anahtar Kelimeler: acetamiprid, imidacloprid, probiotic, Saccharomyces boulardii, SPERM QUALITY, SYSTEM, EXPOSURE, STRESS, CLOTHIANIDIN, APOPTOSIS, CASPASE-3, MECHANISM, DAMAGES, TESTIS
  • Atatürk Üniversitesi Adresli: Evet

Özet

The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, Saccharomyces boulardii supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.