One-Pot Synthesis of Mannich Bases Under Solvent-Free Conditions

DEMİRKOL O., AKBAŞLAR D., Giray S., ANIL B.

SYNTHETIC COMMUNICATIONS, cilt.44, sa.9, ss.1279-1285, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/00397911.2013.853191
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1279-1285
  • Anahtar Kelimeler: beta-dicarbonyl compounds, Solvent-free synthesis, One-pot synthesis, Multicomponent reaction, Mannich bases, AMINO CARBONYL-COMPOUNDS, HIGHLY EFFICIENT CATALYST, STEREOSELECTIVE-SYNTHESIS, 3-COMPONENT SYNTHESIS, ALDEHYDES, ACID, KETONES, DERIVATIVES, IMINES, SYSTEM
  • Atatürk Üniversitesi Adresli: Evet

Özet

A mild and practically convenient one-pot procedure for the Mannich reaction via condensation of amines, aldehydes and malonates, beta-ketoesters, or beta-dicarbonyl compounds has been carried out without using any organic solvent, metallic catalyst, or Lewis acids or bases at room temperature. The present protocol offers several advantages, such as goods yields, simple procedure with easy workup, and the absence of any volatile, hazardous organic solvents and metallic catalyst.