Affinity to some inhibitors of human carbonic anhydrase-1 and bovine carbonic anhydrase

ARSLAN, Öznur; Kufrevioglu, Ömer

doi:10.1080/10934529609376471

Affinity to some inhibitors of human carbonic anhydrase-1 and bovine carbonic anhydrase

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL, cilt.31, sa.8, ss.2017-2022, 1996 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 31 Sayı: 8
Basım Tarihi: 1996
Doi Numarası: 10.1080/10934529609376471
Dergi Adı: JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Environment Index, Greenfile
Sayfa Sayıları: ss.2017-2022
Anahtar Kelimeler: glaucoma, carbonic anhydrase, inhibition, INTRAOCULAR-PRESSURE
Atatürk Üniversitesi Adresli: Evet

Özet

The carbonic anhydrase Isoenzymes employed here have been purifield in high yields by affinity chromatograpy using different affinity gels(Sepharose4B-L-tyrosine-Benzensulfonamide). Inhibition effect of 2-Substituted-1,3,4-Thiadiazole-5-Sulfonamides on human carbonic anhydrase-I (HCA-I) and bovine carbonic anhydrase (BCA) have been determined. It was found that inhibition effects of these compounds on BCA and CA-I were very great.