Preventive effects of hesperidin on diabetic nephropathy induced by streptozotocin via modulating TGF-β1 and oxidative DNA damage

Kandemir F. M., Özkaraca M., Küçükler S., Caglayan C., Hanedan B.

Toxin Reviews, vol.37, no.4, pp.287-293, 2018 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1080/15569543.2017.1364268
  • Journal Name: Toxin Reviews
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.287-293
  • Keywords: Diabetic nephropathy, hesperidin, TGF-1, 8-OHdG, streptozotocin, STRESS, RATS, 8-HYDROXY-2'-DEOXYGUANOSINE, AMELIORATION, INFLAMMATION, RESVERATROL, EXTRACT, ALPHA
  • Ataturk University Affiliated: Yes

Abstract

Hesperidin (HSP) is a natural bioflavonoid with active pharmacological properties. This study was conducted to investigate the hypoglycemic and antioxidant effects of HSP on streptozotocin-induced diabetic nephropathy in rats. Serum urea, creatinine and malondialdehyde levels increased in the diabetic group, while antioxidant enzyme activities decreased compared to the control group. Moreover, transforming growth factor-beta 1 level, 8-hydroxy-2-deoxyguanosine expression and histopathological changes in renal tissue were increased in the diabetic group. On the other hand, HSP therapy significantly regulated these values in diabetic rats. Our results indicated that HSP might be helpful to protect diabetic nephropathy.