Akademik Veri Yönetim Sistemi
HORMONE RESEARCH IN PAEDIATRICS, cilt.94, sa.SUPPL 1, ss.225, 2021 (SCI-Expanded)
Introduction and Aim: FGF-23 is a hormone that works by
inhibiting phosphorus reabsorption in kidneys, and systematic
regulation of phosphate homeostasis by FGF23 depends on the
activity of the membrane protein Klotho. It affects the active vitamin level according to the bioactive free vitamin hypothesis, which
binds DVBP to vitamin D and prolongs its half-life. In this study,
it was aimed to investigate 1.25 (OH) Vitamin D, Vitamin D Binding Protein, FGF-23 and α-Klotho levels and how these parameters changed with the treatment of cholecalciferol in vitamin D
deficiency.
Method: Patients with rickets were included in the study.
Vitamin D, parathormone (PTH), calcium (Ca), phosphorus (P),
alkaline phosphatase (ALP), Fibroblast Growth Factor-23 (FGF23), α-Klotho, vitamin D binding protein (DVBP) levels in blood
samples were examined before and after the treatment. The study
was supported by Ataturk University Scientific Research Projects
Coordination Unit (BAP) with project number 7181.
Results: 16 children under the age of 2 were included in the
study. The average age was 8.57 ± 6.16 months. Two patients (13%)
applied to our clinic with the hypocalcemic seizure. While serum
Ca (p<0.001), P (p<0.001), vitamin D (p <0.01) levels significantly
increased, serum FGF-23 (p <0.05), PTH (p <0.01) and ALP levels
(p<0.01) significantly decreased after cholecalciferol treatment.
There was a positive correlation between serum FGF-23 and PTH
levels (p <0.05).
Conclusion: Serum Ca, P, ALP and PTH levels reached normal levels with cholecalciferol treatment. FGF-23, not α-Klotho
and vitamin D binding protein, plays an important role in rickets
pathophysiology