The Use of Dynamic Contrast-Enhanced Perfusion MRI in Differentiating Benign and Malignant Thyroid Nodules

SAKAT M. S., SADE R., KILIÇ K., GÖZELER M. S., Pala O., POLAT G., ...Daha Fazla

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, cilt.71, ss.706-711, 2019 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s12070-018-1512-3
  • Dergi Adı: INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.706-711
  • Anahtar Kelimeler: Perfusion MRI, Thyroid malignancy, Ktrans, NEEDLE-ASPIRATION-CYTOLOGY, DIAGNOSIS
  • Atatürk Üniversitesi Adresli: Evet

Özet

To investigate the efficacy of perfusion magnetic resonance imaging (MRI) in benign-malignant differentiation of thyroid nodules. Images from 24 patients with thyroid masses were obtained using dynamic contrast enhanced MRI (DCE-MRI) at 3-T MR. DCE-MRI images were evaluated by post-processing of selected regions of interest (ROIs) on software, thus eliciting quantitative data for each voxel within the ROI. Ktrans, Ve, Kep, iAUC and chi(2) were calculated automatically. The DCE-MRI values of benign and malignant lesions were then compared. Mean Ktrans and iAUC values in malignant lesions were significantly lower than those in benign lesions (p=0.028 and 0.049). Ktrans, Kep, and iAUC values in malignant lesions were statistically significantly lower than normal parenchyma values. In contrast to other tissues, the perfusion MRI findings of thyroid masses exhibit a decrease in Ktrans and iAUC values as malignancy increases. Perfusion MRI may be useful in differentiating benign and malignant thyroid nodules once a cut-off value has been determined by other studies.