Rapid and Simple Methods for Determination of Medazepam in Pharmaceutical Preparations using GC-FID and GC-MS

YILMAZ B., Akba V.

ANALYTICAL LETTERS, cilt.42, sa.18, ss.2978-2985, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 18
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/00032710903276596
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2978-2985
  • Atatürk Üniversitesi Adresli: Evet

Özet

This paper describes two rapid, sensitive, and specific methods for the determination of medazepam with internal standard (diazepam) in pharmaceutical preparations by gas chromatography (GC) with flame ionization (FID) and mass spectrometric (MS) detection. The linearity was established over the concentration range of 0.25-5 mu g/mL for GC-FID and 50-1000ng/mL for GC-MS method. The intra- and inter-day relative standard deviation was less than 2.94 and 4.95%, respectively. Developed GC-FID and GC-MS methods in this study are accurate, sensitive, and precise and can be directly and easily applied to Tranko buskas as pharmaceutical preparation.