Determination of carbamazepine in pharmaceutical dosage form using GC-FID

Kadioglu Y., Demirkaya F.

CHROMATOGRAPHIA, cilt.66, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1365/s10337-007-0327-2
  • Dergi Adı: CHROMATOGRAPHIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Atatürk Üniversitesi Adresli: Evet

Özet

The present work describes the methodology and validation of gas chromatography with flame ionization detection (GC-FID) for the determination of carbamazepine with internal standard (diazepam) in pharmaceutical preparations. The method was linear from 2-30 pg mL(-1). The RSD values for precision was less than 9%, accuracy (relative error) was better than 11 % (n = 6). The developed method was successfully applied for the assay of pharmaceutical dosage forms which do not require any preliminary separation or treatment of the samples. The RSD values for Tegretol (R) tablets (200 mg) and Karberol (R) tablets (200 mg) was found to be 4.03 and 3.25%, respectively. The results obtained from this method were compared with the reference method (LC) reported in literature and no significant difference was found statistically.