OXYGEN FREE-RADICAL SCAVENGERS AND REPERFUSION INJURY IN DOG LUNG PRESERVED IN COLD ISCHEMIA

BAŞOĞLU A., KOCAK H., PAÇ M., CERRAHOĞLU M., BAKAN N., YEKELER İ., ...Daha Fazla

THORACIC AND CARDIOVASCULAR SURGEON, cilt.40, sa.3, ss.144-147, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1055/s-2007-1020133
  • Dergi Adı: THORACIC AND CARDIOVASCULAR SURGEON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.144-147
  • Atatürk Üniversitesi Adresli: Evet

Özet

Oxygen-derived free radicals are now considered important contributors to tissue injury associated with ischemia and reperfusion. The purpose of this study was to determine the influence of oxygen free radical scavengers on reperfusion injury. The left lower lobes of 15 canine lungs were isolated, preserved, and then reperfused for 120 minutes. Three groups of lobes were studied: Group 1 (n = 5), without ischemia, group 2 (n = 5) four hours of cold ischemia in Euro-Collins solution, group 3 (n = 5) four hours cold ischemia + oxygen free radical scavenger glutathione (0.1 nmol/L) given at the moment of perfusion. Extravascular lung water (grams per gram of blood-free dry lobe weight) after reperfusion was 2.82 +/- 0.32, 5.06 +/- 0.45, 4.21 +/- 0.33 for groups 1 through 3 respectively (p < 0.001 group 1 versus group 2, p < 0.001 group 2 versus group 3).