Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis

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Küçükler S., Darendelioglu E., Caglayan C., Ayna A., Yıldırım S., Kandemir F. M.

LIFE SCIENCES, cilt.259, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 259
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.lfs.2020.118382
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Apoptosis, Hepatotoxicity, Inflammation, Oxidative stress, Vancomycin, Zingerone, IN-VITRO, PROTECTS, CYTOKINES, NEPHROTOXICITY, ANTIOXIDANT, CELLS, ASSAY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aim: Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methi-cillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity. However, the underlying mechanism of VCM-induced hepatotoxicity is not yet fully understood. Therefore, the current study was designed to evaluate the protective effects of zingerone (Zin) against VCM-induced hepatotoxicity in rats.