LIFE SCIENCES, cilt.259, 2020 (SCI-Expanded)
Aim: Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methi-cillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity. However, the underlying mechanism of VCM-induced hepatotoxicity is not yet fully understood. Therefore, the current study was designed to evaluate the protective effects of zingerone (Zin) against VCM-induced hepatotoxicity in rats.