Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis
LIFE SCIENCES, cilt.259, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 259
- Basım Tarihi: 2020
- Doi Numarası: 10.1016/j.lfs.2020.118382
- Dergi Adı: LIFE SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
- Anahtar Kelimeler: Apoptosis, Hepatotoxicity, Inflammation, Oxidative stress, Vancomycin, Zingerone, IN-VITRO, PROTECTS, CYTOKINES, NEPHROTOXICITY, ANTIOXIDANT, CELLS, ASSAY
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
Aim: Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methi-cillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity. However, the underlying mechanism of VCM-induced hepatotoxicity is not yet fully understood. Therefore, the current study was designed to evaluate the protective effects of zingerone (Zin) against VCM-induced hepatotoxicity in rats.