Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stress
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.126, sa.1, ss.89-93, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 126 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.1080/13813455.2018.1493609
- Dergi Adı: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.89-93
- Anahtar Kelimeler: Astaxanthin, fructose, NF-kappa B, oxidative stress, SIRT1, NF-KAPPA-B, IN-VITRO, SIRT1, PROTEIN, INFLAMMATION, HYPERTENSION, ANTIOXIDANTS, PATHOGENESIS, ACETYLATION, ACTIVATION
- Atatürk Üniversitesi Adresli: Evet
Özet
This study was conducted to determine the effect of astaxanthin (ASX) treatment on alleviation of renal damage in high fructose induced nephrotoxicity in rats. Treatments were arranged in a 2 x 2 factorial fashion: administrations of fructose (30%, via drinking water) and ASX (1 mg/kg/day, within 0.2 ml olive oil) for 8 weeks. Data were analyzed by two-way ANOVA. The ASX treatment decreased serum urea (p < .01) and blood urea-N concentrations (p < .02) at a lower extent in rats receiving fructose than those not receiving fructose. Moreover, the ASX treatment reversed the increases in malondialdehyde (MDA) (p < .0001) and nuclear factor kappa B (NF-kappa B) (p < .0003) levels and the decreases in superoxide dismutase (SOD) activity (p < .0001) and sirtuin-1 (SIRT1) level (p < .0004), in the kidney upon high fructose consumption. The data suggest that ASX supplementation alleviates renal damage induced by high fructose consumption through modulating NF-kappa B/SIRT1 pathway and mitigating oxidative stress.