CLINICAL ORAL INVESTIGATIONS, cilt.27, ss.5977-5989, 2023 (SCI-Expanded)
Objectives Aging is characterized by chronic inflammatory activity. Senescent cells increase with chronic inflammation and age-related pathologies, including periodontal disease. As a critical regulator of tissue inflammaging, we hypothesized that 5a reductase (5 alpha R) is associated with periodontal disease and bacteria-induced senescence in gingival fibroblasts.