<i>Porphyromonas gingivalis</i> enhances the senescence-induced increase of 5-alpha reductase in gingival fibroblasts

Özkan Karasu Y., Orbak R., Kaşalı K., Berker E., Kantarci A.

CLINICAL ORAL INVESTIGATIONS, cilt.27, ss.5977-5989, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00784-023-05211-y
  • Dergi Adı: CLINICAL ORAL INVESTIGATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.5977-5989
  • Anahtar Kelimeler: 5 alpha Reductase, Periodontal disease, Senescence, NECROSIS-FACTOR-ALPHA, SEX STEROID-HORMONES, TNF-ALPHA, TESTOSTERONE, EXPRESSION, ANDROGENS, MEN, INTERLEUKIN-6, METABOLISM, HEALTHY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objectives Aging is characterized by chronic inflammatory activity. Senescent cells increase with chronic inflammation and age-related pathologies, including periodontal disease. As a critical regulator of tissue inflammaging, we hypothesized that 5a reductase (5 alpha R) is associated with periodontal disease and bacteria-induced senescence in gingival fibroblasts.