The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model

TATAR A., YAYLA M., KÖSE D., HALICI Z., YÖRÜK Ö., Polat E.

RHINOLOGY, cilt.54, sa.3, ss.266-272, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4193/rhino15.059
  • Dergi Adı: RHINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.266-272
  • Anahtar Kelimeler: allergic rhinitis, endothelin, endothelin receptor antagonists, bosentan, desloratadine, DESLORATADINE, ANAPHYLAXIS, BOSENTAN, SAFETY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis. Bosentan is a dual endothelin receptor antagonist used to treatment of pulmonary artery hypertension (PAH). In this study, we aimed to determine the role of endothelins in allergic rhinitis (AR) and the effects of endothelin receptor antagonists in AR rat models through comparison with desloratadine.