The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model


TATAR A. , YAYLA M., KÖSE D. , HALICI Z. , YÖRÜK Ö. , Polat E.

RHINOLOGY, cilt.54, ss.266-272, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 54 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4193/rhino15.059
  • Dergi Adı: RHINOLOGY
  • Sayfa Sayısı: ss.266-272

Özet

Objective: Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis. Bosentan is a dual endothelin receptor antagonist used to treatment of pulmonary artery hypertension (PAH). In this study, we aimed to determine the role of endothelins in allergic rhinitis (AR) and the effects of endothelin receptor antagonists in AR rat models through comparison with desloratadine.