Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.)

Gulcin I., Kufrevioglu O., OKTAY M., BUYUKOKUROGLU M.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.90, ss.205-215, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.jep.2003.09.028
  • Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.205-215
  • Anahtar Kelimeler: antioxidant activity, antimicrobial activity, antiulcer activity, analgesic activity, nettle, Urtica dioica L., RADICAL SCAVENGING ACTIVITIES, BENIGN PROSTATIC HYPERPLASIA, TRADITIONAL MEDICINE, FOLK MEDICINE, DANTROLENE SODIUM, BETA-CAROTENE, ROOT EXTRACTS, DOUBLE-BLIND, VITAMIN-E, MELATONIN
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, water extract of nettle (Urtica dioica L.) (WEN) was studied for antioxidant, antimicrobial, antiulcer and analgesic properties. The antioxidant properties of WEN were evaluated using different antioxidant tests, including reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities. WEN had powerful antioxidant activity. The 50, 100 and 250 mug amounts of WEN showed 39, 66 and 98% inhibition on peroxidation of linoleic acid emulsion, respectively, while 60 mug/ml of alpha-tocopherol, exhibited only 30% inhibition. Moreover, WEN had effective reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities at the same concentrations. Those various antioxidant activities were compared to standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), quercetin, and alpha-tocopherol. In addition, total phenolic compounds in the WEN were determined as pyrocatechol equivalent. WEN also showed antimicrobial activity against nine microorganisms, antiulcer activity against ethanol-induced ulcerogenesis and analgesic effect on acetic acid-induced stretching. (C) 2003 Elsevier Ireland Ltd. All rights reserved.