Electrochemical C–H trifluoromethylation of 4-phenylthiazol-2-amines

Yeşilyurt İ., Dağalan Z., ANIL B., Koçak R., BAYRAKÇEKEN NİŞANCI F., NİŞANCI B.

Organic and Biomolecular Chemistry, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1039/d5ob01958c
  • Dergi Adı: Organic and Biomolecular Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, MEDLINE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Herein, we report a new methodology for the electrochemical oxidative C–H trifluoromethylation of 4-phenylthiazol-2-amines in an undivided cell using a glassy carbon electrode (GCE) and sodium trifluoromethanesulfinate (CF3SO2Na; Langlois’ reagent) as the CF3 radical source. Using this tert-butyl hydroperoxide (TBHP)-mediated and transition metal-free effective approach, trifluo-romethylated 4-phenylthiazol-2-amines were synthesized in high yields (up to 97%).