Synthesis and structural characterization of novelO-substituted phenolic and chalcone derivatives with antioxidant activity

Ngameni B., Erdogan M., Kuete V., Dalkilic E., Ngadjui B. T., DAŞTAN A.

JOURNAL OF CHEMICAL RESEARCH, cilt.45, sa.1-2, ss.159-165, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 1-2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1177/1747519820932789
  • Dergi Adı: JOURNAL OF CHEMICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Metadex
  • Sayfa Sayıları: ss.159-165
  • Anahtar Kelimeler: 1,3-dipolar cycloaddition, antioxidant activity, click chemistry, condensation reaction, O-alkylation, triazolated derivatives
  • Atatürk Üniversitesi Adresli: Evet

Özet

A series of novel 4-O-alkyltriazolylphenolic derivatives is first synthesized with good to excellent yields via the click reaction of 3-methoxy-4-O-propargylbenzaldehyde or 3-allyl-4-O-propargylacetophenone and aromatic azide derivatives. Next, the chalcones are prepared via the Claisen-Schmidt method from 4-O-alkylphenylketone derivatives in the presence of the corresponding (hetero)aromatic aldehydes as electrophiles. The structures of the newly synthesized compounds are confirmed from their infrared, nuclear magnetic resonance spectral data, and by elemental analysis. The main advantages of this procedure are the simplicity of the reaction conditions, easily available starting materials, and simple work-up. The antioxidant activity of several of the products is determined using the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) radical scavenging assay. 4-O-propargylvanillin (IC50 = 14.54 mu g/mL) had moderate antioxidant activity.