In vitro assessment of genotoxic and oxidative effects of zinc borate

ÇELİKEZEN F. Ç., TÜRKEZ H., Togar B.

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, cilt.96, sa.5, ss.777-782, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/02772248.2014.983510
  • Dergi Adı: TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.777-782
  • Anahtar Kelimeler: zinc borate, total antioxidant capacity, oxidative stress, sister chromatid exchange, chromosomal aberration, BORON-COMPOUNDS, BORIC-ACID, LYMPHOCYTES, GROWTH, BLOOD
  • Atatürk Üniversitesi Adresli: Evet

Özet

Zinc borate is used as flame retardant for plastics and cellulose fibers, paper, rubber, and textiles. Despite its wide industrial use, there is limited information concerning its toxicity. The aim of the present study was to investigate the concentration dependence (0-280mg L-1) of its genotoxic activity on cultured human lymphocytes by using sister chromatid exchange and chromosomal aberration assays. Total antioxidant capacity and the extent of oxidative stress were also determined. Zinc borate was found to be non-genotoxic at all tested concentrations. It exhibited antioxidant activity at concentrations lower than 40mg L-1, and total oxidative stress levels were not changed at any applied concentration of zinc borate.