Inula graveolens induces selective cytotoxicity in glioblastoma and chronic leukemia cells

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Koc K., Aysin F., Ozek N. S., Geyikoglu F., Taghizadehghalehjoughi A., Abuc O. O., ...Daha Fazla

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, cilt.67, sa.12, ss.1771-1778, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1590/1806-9282.20210614
  • Dergi Adı: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1771-1778
  • Anahtar Kelimeler: Glioblastoma, Myeloid leukemia, Inula, Cell viability, CHEMICAL-COMPOSITION, DOWN-REGULATION, ESSENTIAL OIL, IN-VITRO, AGENTS, TEMOZOLOMIDE, EXPRESSION, APOPTOSIS
  • Atatürk Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Crude oil extracts, components of extracts, and ethanolic extracts of Inula graveolens possess various pharmacological activities on various cancer cells including antioxidative and antiproliferative effects. Aqueous extract of this species has not been investigated on the liquid malignancies and solid tumors with a high incidence of treatment refractoriness and poor survival outcomes such as glioblastoma and leukemia. Hence, the present study aimed to evaluate the cytotoxic efficiency of I. graveolens aqueous extracts on human glioblastoma multiforme and chronic myelogenous leukemia cell lines in comparison to non-cancerous primary rat cerebral cortex and human peripheral blood mononuclear cells.