A Novel Marker of Inflammation: Azurocidin in Patients with ST Segment Elevation Myocardial Infarction

İPEK E., YOLCU M., Yildirim E., ALTINKAYNAK K., Sebin S., KALKAN K., ...Daha Fazla

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, cilt.19, sa.12, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3390/ijms19123797
  • Dergi Adı: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: azurocidine, inflammation, ST segment elevation myocardial infarction, HEPARIN-BINDING PROTEIN, PERCUTANEOUS CORONARY INTERVENTION, C-REACTIVE PROTEIN, RISK SCORE, ORGAN DYSFUNCTION, INTRAVENOUS NPA, MORTALITY, NEUTROPHIL, THROMBOLYSIS, PREDICTION
  • Atatürk Üniversitesi Adresli: Evet

Özet

(1) To investigate the role of azurocidin, an antimicrobial protein, in patients with ST segment elevation myocardial infarction (STEMI). (2) This single-center prospective observational study included patients with STEMI and healthy age- and sex-matched control subjects. Baseline demographic, clinical and biochemical data were compared between the two groups. Azurocidin levels at baseline were determined using an enzyme-linked immunosorbent assay. Multivariate linear regression analysis with enter method was used to test the association between azurocidin and independent variables, such as the thrombolysis in myocardial infarction (TIMI) score, synergy between percutaneous coronary intervention with TAXUS and cardiac surgery score, global registry of acute coronary events score, Killip class, C-reactive protein (CRP), and creatinine kinase-myocardial band (CK-MB). (3) A total of 76 patients with STEMI and 30 healthy control subjects were enrolled in the study. Mean +/- SD azurocidin levels were significantly higher in patients compared with healthy controls (18.07 +/- 13.99 versus 10.09 +/- 5.29 ng/mL, respectively). In a receiver-operating characteristic curve analysis, an azurocidin cut-off level of >11.46 ng/mL had 74% sensitivity and 58% specificity in predicting myocardial infarction. Azurocidin levels had a positive correlation with TIMI score (r = 0.651). In multivariate linear regression analysis, the TIMI score was an independent predictor of the azurocidin level. (4) Azurocidin is an infection marker that may be important in patients with STEMI.