Comparison of reducing effect on lung injury of dexamethasone and bosentan in acute lung injury: an experimental study

ARAZ, Ömer; DEMİRCİ, Elif; Ucar, Elif; Calik, Muhammet; Pulur, Didem; KARAMAN, Adem; YAYLA, Muhammed; ALTUN, Eren; HALICI, Zekai; AKGÜN, Metin

doi:10.1186/2049-6958-8-74

Comparison of reducing effect on lung injury of dexamethasone and bosentan in acute lung injury: an experimental study

ARAZ Ö., DEMİRCİ E., Ucar E. Y., Calik M., Pulur D., KARAMAN A., ...Daha Fazla

MULTIDISCIPLINARY RESPIRATORY MEDICINE, cilt.8, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 8
Basım Tarihi: 2013
Doi Numarası: 10.1186/2049-6958-8-74
Dergi Adı: MULTIDISCIPLINARY RESPIRATORY MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Acute lung injury, Bosentan, Dexamethasone, SEVERE SEPSIS, ENDOTHELIN-1, INFLAMMATION, ARDS
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Atatürk Üniversitesi Adresli: Evet

Özet

Background: Different medical therapies are employed in acute lung injury (ALI) but there is still a debate about the efficacy of these drugs. Among these therapies steroids are clinically applied and bosentan is experimentally studied. The aim of this study was to evaluate the efficacy of these two drugs to treat inflammation in ALI by histopathological comparison.