Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells.

Özdemir Ö., Marinelli L., Cacciatore I., Ciulla M., Emsen B., Di Stefano A., ...Daha Fazla

Zeitschrift fur Naturforschung. C, Journal of biosciences, cilt.76, ss.329-335, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/znc-2020-0093
  • Dergi Adı: Zeitschrift fur Naturforschung. C, Journal of biosciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.329-335
  • Anahtar Kelimeler: AKT1, antiproliferative action, glioblastoma, NSAIDs, PTEN, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, IN-VITRO, CYCLOOXYGENASE-2, APOPTOSIS, AGENTS, GENES
  • Atatürk Üniversitesi Adresli: Evet

Özet

Several epidemiologic, clinical and experimental reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) could have a potential as anticancer agents. The aim of this study was the evaluation of cytotoxic potential in human glioblastoma cells of novel synthesized NSAID derivatives, obtained by linking, through a spacer, alpha-lipoic acid (ALA) to anti-inflammatory drugs, such as naproxen (AL-3, 11 and 17), flurbiprofen (AL-6, 13 and 19) and ibuprofen (AL-9, 15 and 21). The effects on the level of gene expression were also determined using quantitative real-time polymerase chain reaction (qRT-PCR) analysis. According to our results, NSAID derivatives exhibited concentration dependent cytotoxic effects on U87-MG cell line when compared with the control group. Moreover, treatment of the most active compounds (AL-3, AL-6 and AL-9) caused upregulation of tumor suppressor gene PTEN and downregulation of some oncogenes such as AKT1, RAF1 and EGFR. In conclusion, our results revealed that AL-3, AL-6 and AL-9 could be suitable candidates for further investigation to develop new pharmacological strategies for the prevention of cancer.