Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic Anhydrase I (hCA I) and II (hCA II)

Aydin T., Yurtvermez B., Senturk M., KAZAZ C., Cakir A.

RECORDS OF NATURAL PRODUCTS, cilt.13, sa.3, ss.216-225, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.25135/rnp.102.18.07.329
  • Dergi Adı: RECORDS OF NATURAL PRODUCTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.216-225
  • Anahtar Kelimeler: Artemisia dracunculus L., 1-(4 '-methoxyphenyl)-1,2,3-trihydroxypropane, enzyme inhibition, hCA I, hCA II, CHEMICAL-COMPOSITION, ESSENTIAL OIL, INSULIN SENSITIVITY, ETHANOLIC EXTRACT, ISOZYMES I, TARRAGON, CANCER, SECRETION, BIOACTIVES, GLAUCOMA
  • Atatürk Üniversitesi Adresli: Evet

Özet

Tarragon or Dragon's-wort (Artemisia dracunculus L.) is widely used as spice and in traditional medicine in various regions of the world. Inhibitory effects of the n-hexane, dichloromethane, ethanol and methanol extracts of the leaves of tarragon on the human carbonic anhydrase (hCA) I and II enzymes were investigated. Dichloromethane extract exhibited the strongest activity with lowest IC50 value (0.020 and 0.031 mu g/mL, respectively). The chromatographic studies on the dichloromethane extract of tarragon allowed the isolation of six known strong inhibitors of hCA isozymes as trans-anethole, stigmasterol, herniarin, (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide, (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene -8,10 -diyn-1-one and 1-(4'-methoxyphenyl)-1,2,3- trihydroxypropane. The compound, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane was isolated from tarragon for the first time in this study. Among the tested compounds, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane showed the highest inhibitiory impact on both hCA isozymes. Also its IC50 values were found lower than positive control, acetazolamide.