Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation

Pagoni A., Marinelli L., Di Stefano A., Ciulla M., Turkez H., Mardinoglu A., ...Daha Fazla

European Journal of Medicinal Chemistry, cilt.186, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 186
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ejmech.2019.111880
  • Dergi Adı: European Journal of Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Alzheimer's disease, Hybrid, Lipoic acid, Polyphenol, ACID, DERIVATIVES, INHIBITORS, DESIGN, BETA, POLYPHENOLS, DISCOVERY, ESTER
  • Atatürk Üniversitesi Adresli: Hayır

Özet

To date, drugs that hit a single target are inadequate for the treatment of neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases. The development of multitarget ligands, able to interact with the different pathways involved in the progession of these disorders, represents a great challenge for medicinal chemists.