ERCC2 Lys751Gln rs13181 and XRCC2 Arg188His rs3218536 gene polymorphisms contribute to susceptibility of colon, gastric, liver, lung and prostate cancer

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Balkan E., Bilici M., Gündoğdu B., Aksungur N., Kara A., Yasarl E., ...Daha Fazla

JOURNAL OF BUON, cilt.25, sa.1, ss.574-581, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2020
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.574-581
  • Anahtar Kelimeler: colon, ERCC2, gastric, liver, lung, prostate cancer, DNA-REPAIR GENE, EXCISION-REPAIR, COLORECTAL-CANCER, RISK, NUCLEOTIDE, ASSOCIATION, ASP312ASN, VARIANTS, XPD
  • Atatürk Üniversitesi Adresli: Evet

Özet

Purpose: Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. The relationship between genetic polymorphisms and cancer risk has been extensively researched. In the present study, we evaluated the association between polymorphisms in two DNA repair genes, ERCC2 Lys751Gln (rs13181) and XRCC2 Arg188His (rs3218536) and the risk of colorectal, stomach, liver, prostate and lung cancer.