Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities

GÜL H. İ., TUĞRAK M., Sakagami H.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, sa.1, ss.147-151, 2016 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/14756366.2015.1014474
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.147-151
  • Anahtar Kelimeler: Acrylophenone, cytotoxicity, Mannich bases, N-methylpiperazine, MONO-MANNICH BASES, CORRESPONDING AZINE DERIVATIVES, JURKAT CELLS, 1-ARYL-2-DIMETHYLAMINOMETHYL-2-PROPEN-1-ONE HYDROCHLORIDES, 1-ARYL-3-PHENETHYLAMINO-1-PROPANONE HYDROCHLORIDES, CELLULAR GLUTATHIONE, BIOLOGICAL-ACTIVITY, STYRYL KETONES, CANCER CELLS, SOLID TUMORS
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, the compounds having acrylophenone structure, 1-aryl-2-(N-methylpiperazinomethyl)-2-propen-1-one dihydrochlorides, were synthesized and their chemical structures were identified with H-1 NMR, C-13 NMR and HRMS spectra. The cytotoxicities of the compounds were tested towards Ca9-22 (human gingival carcinoma), HSC-2 (human oral squamous carcinoma), HSC-3 (human oral squamous carcinoma) and HSC-4 (human oral squamous carcinoma) cell lines as tumor cell lines and HGF (gingival fibroblasts), HPLF (periodontal ligament fibroblasts) and HPC (pulp cells) cell lines as non-tumor cell lines. PSE of the compound TA2, which has a methyl substituent on phenyl ring, pointed out the compound TA2 as a leader compound to be considered.