Effects of propofol alone or in combination with ketamine on intraocular pressure in unpremedicated dogs

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Şenocak M. G., Yanmaz L. E.

VETERINARY OPHTHALMOLOGY, cilt.27, sa.2, ss.139-147, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1111/vop.13127
  • Dergi Adı: VETERINARY OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.139-147
  • Anahtar Kelimeler: intraocular pressure in dogs, ketamine, ketofol, propofol, total intravenous anesthesia, oxygen, CARDIOVASCULAR PARAMETERS, ANESTHESIA, INDUCTION, RECOVERY, KETOFOL, SEVOFLURANE, SEDATION, QUALITY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective To determine the effects of propofol (P) alone and in combination with ketamine (KP) at ratios of 1:1, 1:2, and 1:3 on intraocular pressure (IOP) in unpremedicated dogs.Animals Studied A total of 28 cross-bred healthy dogs.Procedures Dogs were randomly assigned to one of four groups (n = 7 per group) to receive intravenous P or KP at 1:1, 1:2, and 1:3 ratios, respectively. The infusion was administered at 0.6 mg/kg/min for 60 min. IOP, cardiorespiratory variables, rectal temperature (RT), and pedal reflex were recorded every 5 min for 60 min, starting from baseline (BL).Results There was a statistically significant increase in IOP in all groups: P (p = .011), KP 1:1 (p = .003), KP 1:2 (p = .023), and KP 1:3 (p = .008). The IOP increase was less pronounced in the KP 1:2 group and was only significant (p = .023) at T45 compared with BL. A significant correlation was observed between IOP and SpO(2) in P (r = -.215, p = .02), KP 1:2 (r = -.579, p < .01), and KP 1:3 (r = -.402, p < .01) groups. IOP significantly increased due to decreased SpO(2) below 86.5% (p < .05).Conclusions Propofol alone and in combination with ketamine may increase preexisting IOP in unpremedicated dogs. SpO(2) levels below 86.5% may trigger an increase in IOP. Administering KP in a 1:2 ratio at an infusion rate of 0.6 mg/kg/min does not significantly alter IOP for under 45 min in unpremedicated dogs with sufficient oxygenation.