Preventative Effect of Vitamin E on Mast Cells in Carbon Tetrachloride-induced Acute Liver Damage

ERALP, AYHAN; Menguc, Nur; POLAT, Elif; YÜNCÜ, MEHMET; KORUK, MEHMET; Demir, Serap; SARI, İBRAHİM

doi:10.2174/1871530316666161029205427

Preventative Effect of Vitamin E on Mast Cells in Carbon Tetrachloride-induced Acute Liver Damage

ERALP A., Menguc N. Y., POLAT E., YÜNCÜ M., KORUK M., Demir S. S. I., ...Daha Fazla

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, cilt.16, sa.3, ss.205-212, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 16 Sayı: 3
Basım Tarihi: 2016
Doi Numarası: 10.2174/1871530316666161029205427
Dergi Adı: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.205-212
Atatürk Üniversitesi Adresli: Evet

Özet

Background: Preventing liver damage that might lead to cirrhosis is very important in the early stages of injury to that organ. The role of mast cells (MCs) in liver injuries has been long debated, and vitamin E is a well-known antioxidant used to treat those injuries. This study aimed to determine the protective role of vitamin E on MCs in injury to the liver that is triggered by carbon tetrachloride (CCl4). There is a correlation between MC deposits and improvement in fibrosis tissues.