SYNTHESIS OF TRIIODOANILINE, PREPARATION OF NANOSUSPENSIONS, IN VITRO CHARACTERIZATION AND INVESTIGATION OF RADIOCONTRAST PROPERTIES TRİİYODOANİLİN'İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ


KOCA M., ÖZAKAR E., SEVİNÇ ÖZAKAR R.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.46, no.2, pp.264-283, 2022 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.33483/jfpau.811737q
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.264-283
  • Keywords: CT imaging, nanocrystal, nanosuspension, radiocontrast agent, triiodoaniline
  • Ataturk University Affiliated: Yes

Abstract

© 2022 University of Ankara. All rights reserved.Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging. Material and Method: TIA synthesis was obtained using ultrasonic sound waves, and nanocrystals were obtained by nanoprecipitation method from this synthesized substance. NMR and Q-TOF analyzes were performed for the characterization of TIA. For the characterization of nanocrystals, optical microscope, zeta potential, particle size, and distribution, SEM and FT-IR analyzes were performed. The obtained nanosuspension was compared by the CT technique with iopromide and iohexol in terms of radiocontrast properties. Result and Discussion: The size of the prepared nanoparticles based on the synthesized pure TIA was found to be ~699 nm and zeta potentials as ~ (-)16 mW. Morphologies were determined by SEM and optical microscope images. It was determined by FT-IR that the obtained nanocrystals do not exhibit a different structure than the synthesized TIA. On CT images, TIA nanosuspension was found to exhibit ~ 40% more contrast than the same amount of iopromide and iohexol. As a result, it has been shown that nanocrystals can perform similar imaging by using less radiocontrast materials with their unique properties. In this way, it is likely to cause fewer side effects and/or toxic effects due to the lower dosage. In the light of these successful results, it is planned to detail this study with clinical trials in the future.