Can the Rosa canina Plant be Used Against Alkylating Agents as a Radical Scavenger?

Kizilet H., Kasimoglu C., UYSAL H.

POLISH JOURNAL OF ENVIRONMENTAL STUDIES, cilt.22, sa.4, ss.1263-1267, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2013
  • Dergi Adı: POLISH JOURNAL OF ENVIRONMENTAL STUDIES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1263-1267
  • Anahtar Kelimeler: Drosophila melanogaster, Rosa canina, EMS, SMART, antigenotoxicity, ETHYL METHANESULFONATE, ANTIOXIDANT ACTIVITY, MUTAGENICITY, MUTATION, EXTRACT, FRUITS
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study we used the somatic mutation and recombination test (SMART) in Drosophila melanogaster to evaluate the genotoxicity of ethyl methanesulfonate (EMS) and the effect of Rosa canina L. ethanol extract (RCeta) on the genotoxicity of EMS. Application groups were prepared as Drosophila instant medium (DIM), including only 1ppm EMS and different concentrations (1, 2, and 4ppm) of RCeta were added to DIM, including 1 ppm EMS. As a result of our study, statistically significant genotoxic effects of EMS (P<0.05) were removed by RCeta. A particularly positive genotoxic effect of EMS has become inconclusive/negative efficacy in both wing phenotypes on 2 and 4 ppm EMS+RCeta application groups.