Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer

Kaynar H., Meral M., Turhan H., Keles M., Celik G., Akcay F.

CANCER LETTERS, cilt.227, sa.2, ss.133-139, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 227 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.canlet.2004.12.005
  • Dergi Adı: CANCER LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.133-139
  • Anahtar Kelimeler: malondialdehyde, glutathione, glutathione peroxidase, superoxide dismutase, nitric oxide, small cell and non-small cell lung cancer, CHRONIC LYMPHOCYTIC-LEUKEMIA, HUMAN TUMOR-CELLS, LIPID-PEROXIDATION, OXIDATIVE STRESS, ANTIOXIDANT ENZYMES, OXIDANT/ANTIOXIDANT STATUS, BREAST-CANCER, PLASMA, CARCINOMA, BLOOD
  • Atatürk Üniversitesi Adresli: Evet

Özet

Lung cancer is a common pathology with high mortality due to late diagnosis. Glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), catalase (CAT), xanthine oxidase (XO), Cu-Zn superoxide dismutase (Cu-Zn SOD) activities, total glutathione (TGSH), nitric oxide (NO center dot), and malondialdehyde (MDA) levels were investigated in erythrocytes of patients with non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC), and healthy control group. We aimed to investigate serum GSH, GSH-dependent enzymes activities (GSH-Px and GST), XO, CAT, Cu-Zn SOD activity, and NO center dot, and MDA levels in patients with NSCLC and with SCLC and correlate with the cancer stage.