Total oxidant-antioxidant and paraoxonase-1 levels in premenstrual dysphoric disorder: a follow-up study

ÖZCAN H., ORAL E., Gulec M., TÜRKEZ H., Gulec T. C., ÜSTÜNDAĞ M. F., ...Daha Fazla

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, cilt.27, sa.2, ss.116-124, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/24750573.2017.1326735
  • Dergi Adı: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.116-124
  • Anahtar Kelimeler: Estrogen, progesterone, oxidant, antioxidant, paraoxonase-1, premenstrual dysphoric disorder, MAJOR DEPRESSION, OXIDATIVE STRESS, LIPID-PEROXIDATION, SLEEP-DEPRIVATION, L-TRYPTOPHAN, INFLAMMATION, WOMEN, MARKER, ADRENOMEDULLIN, AVAILABILITY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) that was categorized as a mood disorder in the most recent version of the Diagnostic and Statistical Manual for Mental Disorders. In addition to a history of PMS, a PMDD diagnosis requires prospective symptom assessment for 2 consecutive menstrual periods. Although the effects of some oxidants-antioxidants were previously studied in PMS, their possible effects in PMDD remain unknown. Paraoxonase-1 (PON-1) is a new high-density lipoprotein-associated enzyme with many antioxidative effects. We hypothesized that assessing serum total oxidant-antioxidant and PON-1 levels could clarify the role of oxidant-antioxidant system in PMDD.