Reaction of 9-oxabicyclo[4.2.1]non-7-ene-1-ol with tetrazine: An unusually facile intramolecular rearrangement

KAYA A., SALAMCI E., MENZEK A., ERDEM S., ŞAHİN E., ECER K.

TETRAHEDRON, cilt.73, sa.36, ss.5381-5388, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 36
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.tet.2017.07.040
  • Dergi Adı: TETRAHEDRON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5381-5388
  • Anahtar Kelimeler: Diels Alder, Caprolactone, DFT, Mechanism, 1,4-Epoxide, Rearrangement, Retro-ene, Tetrazine, BICYCLIC ENDOPEROXIDES, SYNTHETIC APPLICATIONS, CYCLOADDITION REACTION, ENE REACTION, DOUBLE-BOND, MECHANISM, THERMOLYSIS, DERIVATIVES, CONVERSION, CHEMISTRY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Reaction of (1S(*), 7R(*))-9-oxabicyclo[4.2.1]non-7-en-1 -ol (5) with dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate (6) produced (2R(*),4R(*))-dimethyl 4-(7-oxooxepan-2-yl)-1,4-dihydropyridazine-3,6-dicarboxylate (11) in a one-pot reaction involving cycloaddition at ambient conditions. The structure of the rearrangement product 11 was determined by X-ray crystallographic analysis. Its formation was discussed based on experimental studies and density functional theory calculations. The driving force of this unusually facile reaction was the stability of the caprolactone product 11 and the extremely exorgenic loss of N-2. Structural factors facilitating this rearrangement were also explored employing PCM//M06-2X/6-31G(d, p) calculations. (C)2017 Elsevier Ltd. All rights reserved.