Antioxidant enzyme activities and lipid peroxidation levels in erythrocytes of patients with oesophageal and gastric cancer

Dursun H., Bilici M., Uyanik A., Okcu N., AKYÜZ M.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.34, sa.2, ss.193-199, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1177/147323000603400209
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.193-199
  • Anahtar Kelimeler: cancer, stages, oxidative stress, lipid peroxidation, catalase, glutathione peroxidase, superoxide dismutase, free radicals, NITRIC-OXIDE LEVELS, OXIDATIVE STRESS, OXIDANT/ANTIOXIDANT STATUS, GLUTATHIONE PEROXIDASE, TUMOR PROGRESSION, LARYNGEAL-CANCER, BREAST-CANCER, DAMAGE, BLOOD, CELLS
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, levels of lipid peroxidation and antioxidant enzyme activities were investigated in the erythrocytes of patients with oesophageal and gastric cancers. Erythrocytes were obtained from 17 patients with oesophageal cancer, 37 patients with gastric cancer and 20 healthy controls. Levels of malondialdehyde (MDA), a lipid peroxidation marker, and activities of copper- and zinc-containing superoxide dismutase (CuZnSOD), catalase (CAT) and glutathione peroxidase (GPx) were determined using spectrophotometric methods. MDA levels and CuZn-SOD activity were significantly higher and GPx and CAT activities significantly lower in patients with oesophageal and gastric cancer than in controls. There were no statistically significant differences in the parameters measured in relation to disease stage in either patient group. These results indicate significant changes in the antioxidant defence system in patients with oesophageal and gastric cancer. It is postulated that this may lead to enhanced action of oxygen radicals, resulting in lipid peroxidation.