In Vitro Assessment of Hemostatic Performances of Salvia verticillata, Achillea biebersteinii, Tragopogon aureus, and Cephalaria procera

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Karakaya S., Tozlu Ö. Ö., İncekara Ü., Türkez H., Aksakal Ö.

3rd INTERNATIONAL SYMPOSIUM ON BIODIVERSITY RESEARCH, Erzurum, Türkiye, 20 - 22 Ekim 2021, ss.181

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Erzurum
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.181
  • Atatürk Üniversitesi Adresli: Evet

Özet

Hemostasis is an inherent function and natural processes to prevent or stop bleeding. Nowadays great efforts are being made to develop novel, economic and high-performance products to control bleeding. In this study, we aimed to assess the in vitro hemostatic effects by four several plant species used in folk medicine for different purposes including Salvia verticillata, Achillea biebersteinii, Tragopogon aureus, and Cephalaria procera. The extracts with different solvent nature were prepared and their hemostatic efficacy were determined using optical aggregometry. The present results clearly revealed that the extracts of S. verticillata showed the highest efficacy on platelet aggregation in presence of adenosine-diphosphate (ADP) (80.77%), collagen (80.78%), and arachidonic acid (AA) (73.71%) when compared to other plant extracts. Again, the most effective platelet aggregation (47.27%) was determined after application C. procera with in the presence of epinephrine (EPI). Moreover, we firstly executed that n-butanol and ethyl acetate extracts led to the highest percantages of platelet aggregation in the presence of APD, collagen, AA and EPI. In a conclusion, our findings suggested that the tested medicinal plants in particular S. verticillata and C. procera could be novel and natural sources of effective hemostatic agents.