Azaindole-BODIPYs: Synthesis, fluorescent recognition of hydrogen sulfate anion and biological evaluation

Keşan G., Topaloğlu B., Özcan E., Kazan H. H., Eçik E., Şenkuytu E., ...Daha Fazla

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, cilt.213, ss.73-82, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 213
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.saa.2019.01.047
  • Dergi Adı: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-82
  • Anahtar Kelimeler: Borondipyrromethenes, Azaindole, Hydrogen sulfate, Anionsensor, Fluorescence, Chemosensor, K562 cell lines, DFT, EFFICIENT ENERGY-TRANSFER, PHOTOPHYSICAL PROPERTIES, AQUEOUS-SOLUTION, DYES SYNTHESIS, SENSOR, DESIGN, CHEMOSENSOR
  • Atatürk Üniversitesi Adresli: Evet

Özet

The synthesized and sensing capability of two novel azaindole substituted mono and distyryl BODIPY dyes against bisulfate anion were reported. Structural characterizations of the targeted compounds were conducted by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, H-1 and C-13 NMRspectroscopies. Photophysical properties of the azaindole substituted BODIPY compounds were investigated employing absorption and fluorescence spectroscopies in acetonitrile solution. It was found that the final compounds 3 and 4 exhibited exclusively selective and sensitive turn-off sensor behavior on HSO4- anion. Additionally, the stoichiometry ratio of the targeted compounds to bisulfate anion was measured 0.5 by Job's method. Also, density function theory was performed to the optical response of the sensor for targeted compounds. Furthermore, the cytotoxicity of Azaindole-BODIPYs was examined against living human leukemia K562 cell lines. (C) 2019 Elsevier B.V. All rights reserved.