Akademik Veri Yönetim Sistemi
60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, İtalya, 15 - 17 Eylül 2022, ss.108-109
Introduction: The hypothalamo-pituitary system is activated
as puberty begins and GnRH release occurs as well as the synthesis
of many hormones. These hormones cause changes on muscle
development, body fat distribution. In this study, changes in miyostatin,
irisin, kisspeptin, omentin and leptin levels and the relationship
of these changes with physical properties and fat tissue were
investigated.
Material and Method: A total of 150 healthy children; between
the ages of 8 and 16; with equal distribution of boys and girls; were
included in the study. Serum irisin, omentin, leptin, kisspeptin and
myostatin levels were analyzed by ELISA method.
The study was supported by the Scientific Research Projects
Commission of Atatürk University with the code
TTU-2020-8610.
Results: Serum leptin level was 322.27 Å} 773.64 μL in girls and
228.89 Å} 713.84 μL in boys. The serum omentin level was 37.2 Å}
16.47 ng/ml in boys and 31.25 Å} 17.84 ng/ml in girls, and there
were significant differences between genders, respectively
(p<0.001, <0.05). In addition, irisin hormone (p=0.015) and leptin
hormone increased statistically significantly as Tanner stage
increased in female cases (p<0.05).
When the relationship between the anthropometric measurements
of the cases and biochemical values of the cases is evaluated;
in male cases; between irisin and hip circumference (p<0.001) and
BMI (p=0.024), between leptin and hip circumference (p=0.005)
and BMI (p=0.001) statistically significant relationship was
observed. No correlation was found between other parameters.
Also, when investigating the relationship between these hormones;
a highly significant positive relationship was found between myostatin
and kisspeptin and omentin, and between kisspeptin and
irisin (p<0.001). Further, a statistically significant positive relationship
was observed between kisspeptin and omentin (p=0.002)
and leptin (p=0.043).
Conclusion: In addition to increases in height, weight, BMI,
waist, hip circumference, waist/hip circumference ratio, there
were significant increases in FSH, LH and E2 levels as puberty progresses.
While the waist/hip circumference ratio was higher in
boys, indicating central fat deposition in boys. Also, the fact that serum omentin levels were found to be lower and serum leptin
levels higher in girls during puberty, emphasizes that serum omentin
and leptin levels at puberty are affected by gender.