The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

KUYRUKLUYILDIZ U., KÜPELİ İ., BEDİR Z., ÖZMEN Ö., ONK D., SÜLEYMAN B., ...Daha Fazla

Turkish Journal of Anesthesia and Reanimation, cilt.44, sa.6, ss.287-294, 2016 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/tjar.2016.02212
  • Dergi Adı: Turkish Journal of Anesthesia and Reanimation
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.287-294
  • Anahtar Kelimeler: Paclitaxel, anakinra, peripheral neuropathy, pain, oxidative stress, ANTAGONIST ANAKINRA, HYPERALGESIA, MODEL, VINCRISTINE, INJURY, MAINTENANCE, OXALIPLATIN, RECEPTORS, HUMANS, SYSTEM
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Paclitaxel is used in the treatment of cancer, and it may cause interleukin-1 beta (IL-1 beta)-related peripheral neuropathic pain. While our primary aim was to investigate the analgesic efficacy of an IL-1 beta antagonist, a secondary outcome was to assess whether a correlation exists between analgesic effects and antioxidant activity.