Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties

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Köse D., Ün H., Uğan R. A., Halıcı Z., Çadırcı E., Bal T., ...Daha Fazla

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.73, sa.10, ss.1302-1309, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1093/jpp/rgab088
  • Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1302-1309
  • Anahtar Kelimeler: polymicrobial sepsis, aprepitant, tumour necrosis factor alpha, nuclear factor-kappa b, NEUROKININ-1 RECEPTOR ANTAGONISTS, CECAL LIGATION, ANIMAL-MODELS, INFLAMMATORY CYTOKINES, OXIDATIVE STRESS, SEPSIS, LIVER, RATS, INHIBITION, ACTIVATION
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objectives: We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.