Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties
JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.73, sa.10, ss.1302-1309, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 10
- Basım Tarihi: 2021
- Doi Numarası: 10.1093/jpp/rgab088
- Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1302-1309
- Anahtar Kelimeler: polymicrobial sepsis, aprepitant, tumour necrosis factor alpha, nuclear factor-kappa b, NEUROKININ-1 RECEPTOR ANTAGONISTS, CECAL LIGATION, ANIMAL-MODELS, INFLAMMATORY CYTOKINES, OXIDATIVE STRESS, SEPSIS, LIVER, RATS, INHIBITION, ACTIVATION
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
Objectives: We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.