Can exhaled nitric oxide (FeNO) serve as a clinical indicator for patients hospitalized with Crimean-Congo Hemorrhagic Fever?

Kerget F., Kerget B.

JAPANESE JOURNAL OF INFECTIOUS DISEASES, cilt.76, sa.1, ss.226-232, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.7883/yoken.jjid.2022.470
  • Dergi Adı: JAPANESE JOURNAL OF INFECTIOUS DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.226-232
  • Atatürk Üniversitesi Adresli: Evet

Özet

Crimean-Congo Hemorrhagic Fever (CCHF), a zoonotic disease spread by infected viruses, can be a significant cause of morbidity and mortality in endemic areas. This prospective study aimed to establish a connection between exhaled nitric oxide (FeNO) levels and the clinical prognosis of CCHF. The study included a total of 85 participants: 55 patients followed for CCHF between May and August 2022 and 30 healthy controls. The patients' FeNO levels were measured at admission to the hospital. FeNO levels were 7.6 ± 3.3 parts per billion (ppb) in patients with mild/moderate CCHF, 2.5 ± 2.1 ppb in patients with severe CCHF, and 6.7 ± 1.7 ppb in the healthy control group. There was no statistically significant difference in FeNO between the control group and patients with mild/moderate CCHF (p=0.09), whereas patients with severe CCHF had lower FeNO levels than both the control group and patients with mild/moderate CCHF (p < 0.001 for both). FeNO measurement may offer a noninvasive, easily applied approach for predicting the clinical course and prognosis of CCHF in the early stages of the disease.