OXIDATION COMMUNICATIONS, cilt.38, sa.3, ss.1252-1264, 2015 (SCI-Expanded)
The present study was carried out to examine the antioxidant, antimicrobial and haemolytic activities of different extracts, fractions and oils (essential and fixed) of Diarthron vesiculosum. GC-MS analysis revealed the presence of 18 and 16 compounds in the essential and fixed oils, respectively with 1,2-benzenedicarboxylic acid, diisooctyl ester (35.94 %), 1-(+)-ascorbic acid 2,6-dihexadecanoic (12.24%), Z,Z-3,13-octadecadien-1-ol (14.08 %), 9,12-octadecadienoic acid (Z,Z)-2,3-dihydroxypropyl ester (11.02%) as the major components. The extracts contained appreciable levels of total phenolic and total flavonoid contents and exhibited good DPPH radical scavenging activity, (IC50 0.39-21.5 mg/ml), and inhibition of peroxidation in linoleic acid system (65.8-89.3%). Moderate to high antimicrobial activity against selected strains of bacteria and fungi was observed. The extracts exhibited 2.84 to 13.15% haemolysis of red blood cells. The results of the present investigation demonstrated significant (p < 0.05) variations in the antioxidant, antimicrobial and haemolytic potential of the plant extracts and fractions.