A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on Glutamate Transporter Activity in Chronic Depression

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YENİ Y., ÇAKIR Z., HACIMÜFTÜOĞLU A., TAGHIZADEHGHALEHJOUGHI A., OKKAY U., Genc S., ...Daha Fazla

Journal of Personalized Medicine, cilt.12, sa.2, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3390/jpm12020246
  • Dergi Adı: Journal of Personalized Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: depression, glutamate, H4, hippocampus, JNJ7777120, CHRONIC MILD STRESS, OXIDATIVE STRESS, LOCUS-COERULEUS, EXPRESSION, RAT, RELEASE, SUSCEPTIBILITY, EXCITOTOXICITY, NEUROBIOLOGY, GLUTATHIONE
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2022 by the authors. Licensee MDPI, Basel, Switzerland.Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as the main immune system histamine receptor with a pro-inflammatory role. To understand the role of this receptor, the drug JNJ7777120 was used to reveal the chronic depression-glutamate relationship. We have important findings showing that the H4 antagonist increases the glutamate transporters’ instantaneous activity. In our experiment, it has been shown that blocking the H4 receptor leads to increased neuron cell viability and improvement in behavioral ability due to glutamate. Therefore, JNJ can be used to prevent neurotoxicity, inhibit membrane phospholipase activation and free radical formation, and minimize membrane disruption. In line with our findings, results have been obtained that indicate that JNJ will contribute to the effective prevention and treatment of depression.