Oxidative Renal Damage in Rats Subjected to Ovarian Ischemia Reperfusion and Protective Effect of Tianeptine


KARACA İ., DELİBAŞ İ. B., YAPÇA Ö. E., İNGEÇ M., KUMBASAR s., HİRİK E., ...More

LATIN AMERICAN JOURNAL OF PHARMACY, vol.36, no.12, pp.2339-2347, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 12
  • Publication Date: 2017
  • Journal Name: LATIN AMERICAN JOURNAL OF PHARMACY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2339-2347
  • Ataturk University Affiliated: Yes

Abstract

Ischemia reperfusion (I/R) injury in an organ can also cause damage in other organs. The aim of this study was to research the effect of tianeptine on oxidative ovarian injury induced by I/R in rats, and on the complication of this damage on the kidney. Albino Wistar female rats were assigned into groups, control subjected to ovarian I/R (OIR), exposed to 25 mg/kg tianeptine + ovarian I/R (TOIR), sham operation + 25 mg/kg tianeptin (TSG) and sham operated (SHAM). MDA, MPO, TNF-alpha and IL-1 beta levels in OIR group were found to be significantly higher compared to the TOIR, TSG and SHAM groups, and the tGSH level was found to be lower. Histopathologically, dilated and congested blood vessel, edema, hemorrhage, and PNL infiltration were observed in the OIR group ovarian and kidney tissues. In the ovarian and kidney tissues of TOIR group, dilated and congested blood vessel was found. This information obtained suggests that tianeptine may be useful in the treatment of ovarian I/R injury and its complications on kidney.