Expression profiles of inflammatory cytokines in Behçet’s disease treated with cyclosporine and colchicine

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Diyarbakır E., ATEŞ O., KELEŞ S., DOĞAN H., EYERCİ N., BİLEN H., ...Daha Fazla

Sylwan, cilt.159, sa.1, ss.470-481, 2015 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 159 Sayı: 1
  • Basım Tarihi: 2015
  • Dergi Adı: Sylwan
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.470-481
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Behçet’s disease is an idiopathic, chronic, and inflammatory recurrent disease

characterized by episodic pan-uveitis, vasculitis of the arteries and veins, and endothelial

dysfunction. The aim of this study was to investigate the expression profiles of the

inflammatory cytokines IL-1β, IL-2, IL-6, TNF-α, Hsp60, and TLR4 in Behçet’s disease and

to compare the effects of cyclosporine (n=16) and colchicine (n=24) administration on the

expression of these inflammatory cytokines.

Methods: Blood samples were obtained from 40 unrelated patients with Behçet’s disease

being treated with cyclosporine or colchicine and 30 healthy controls. The expression levels

of IL-1β, IL-2, IL-6, TNF-, Hsp60, and TLR4 were analyzed by real-time polymerase chain

reaction (RT-PCR).

Results: There was a statistically significant decrease in expression levels of IL-1β, IL-6, and

TLR4 in patients with Behçet's disease compared to levels in the healthy controls (p<0.05).

No statistical differences were found in cytokine expression levels between patients using

cyclosporine and colchicine (p>0.05).

Conclusion: Changes in expression levels of inflammatory cytokines may suggest an

association with the etiology or recurrence of Behçet’s disease.

Keywords: Behçet’s disease, inflammation, cytokines, cyclosporine, colchicine