Akademik Veri Yönetim Sistemi
Acta Physiologica, cilt.227, ss.190, 2019 (SCI-Expanded)
Osteoarthritis (OA) is a chronic and degenerative
disease that characterized by imbalance between the
events of making and destroying the periarticular bone,
degeneration of articular cartilage. It mostly occurs in
the knee joint. Daidzein (DZ) is a kind of
phytoestrogens of isoflovane group commonly that
found in many plants. The aim of this study was to
investigate the effects of DZ on the inflammatory
markers that has an important role in the pathogenesis
of OA. The protocol of this study was confirmed by
Local Ethics Committee of Laboratory Animals
Experiments of Ataturk University, Erzurum, Turkey. In
this study; Experimental knee osteoarthritis was formed
by monoiodoacete by intraarticular (ia) injection.
Twelve weeks age rats divided into 7 groups (Control
(untreatment), OA+saline, OA+DZ oral, OA+DZ ia,
OA+hyaluronic acid (HA) ia, OA+DZ oral+HA ia and
OA+DZ+HA ia. In oral groups, DZ was administered
with gavage twice daily for 21 days. In ia groups, DZ,
HA and saline were injected ia at 1st,7th, 14th and 21th
day of the experiment. At the end of the experiment
blood samples were taken for evaluating serum TNF-α
and IL-1β inflammatory markers with ELISA kits.
Results showed that serum TNF-α and IL-1β levels
decreased in the treatment groups compared to the
OA+saline group. But, OA+DZ oral+HA ia group was
only statistically significant decreased than OA+saline
group (p<0.05). It has been demonstrated that DZ has
anti inflammatory effect. At the same time, the results
of the study show that DZ alone and/or in combination
with HA may be useful in the treatment of knee OA.