The investigation of the protective effects of nimesulide on experimental testicular ischemia-reperfusion injury in rats

POLAT E. C., Bozkurt A. S., KESKİN ÇİMEN F., GÜLABOĞLU M., ALTUNER D.

REVISTA INTERNACIONAL DE ANDROLOGIA, cilt.18, sa.2, ss.55-62, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.androl.2018.08.001
  • Dergi Adı: REVISTA INTERNACIONAL DE ANDROLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.55-62
  • Atatürk Üniversitesi Adresli: Evet

Özet

Introduction and objectives: Testicular ischennia/reperfusion (I/R) injury develops after torsion and following detorsion of the testis. Reactive oxygen species were produced and oxidative damage begins to occur due to I/R process. Nimesulide, which is a specific cyclooxygenase-2 inhibitor drug, have antioxidant, antiinflammatory, analgesics and antipyretic effects. We aimed to investigate biochemically and histopathologically effect of nimesulide on testis I/R injury in rats induced by the testicular torsion-detorsion.