Effect of high fat diet on the volume of liver and quantitative feature of Kupffer cells in the female rat: A stereological and ultrastructural study

Kiki I., Altunkaynak B. Z., Altunkaynak M. E., Vuraler O., Unal D., Kaplan S.

OBESITY SURGERY, cilt.17, sa.10, ss.1381-1388, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s11695-007-9219-7
  • Dergi Adı: OBESITY SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1381-1388
  • Anahtar Kelimeler: high fat diet, Kupffer cell, liver, volume, stereology, CAVALIERI PRINCIPLE, ARBITRARY PARTICLES, UNBIASED ESTIMATION, STEATOHEPATITIS, NUMBER
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: The role of Kupffer cells (KCs) in nonalcoholic; steatohepatitis (NASH) which is regarded as a major cause of cryptogenic cirrhosis of the liver was investigated using stereological methods and electron microscopy in the rat model. To our knowledge, there is no stereological study on the volume of liver, total number, numerical density, and nuclear height of KCs of liver in the female rat fed with a high fat diet (HFD) in the literature.