Plasma values of oxidants and antioxidants in acute brain hemorrhage - Role of free radicals in the development of brain injury

Aygcul R., Demircan B., Erdem F., Ulvi H., Yildirim A., Demirbas F.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.108, ss.43-52, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 108
  • Basım Tarihi: 2005
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.43-52
  • Anahtar Kelimeler: brain hemorrhage, lipid peroxidation, reactive oxygen species, oxidative brain injury, antioxidant enzymes, xanthine oxidase, nitric oxide, malondialdehyde, EXPERIMENTAL INTRACEREBRAL HEMORRHAGE, LIPID-PEROXIDATION PRODUCTS, CENTRAL-NERVOUS-SYSTEM, XANTHINE-OXIDASE, ISCHEMIC BRAIN, GLUTATHIONE PEROXIDASE, SUPEROXIDE-DISMUTASE, REOXYGENATION INJURY, NITRIC-OXIDE, BLOOD-FLOW
  • Atatürk Üniversitesi Adresli: Evet

Özet

The levels of oxidants xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA) and of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione reductase (GRID) were determined in plasma within 24 h after onset of hemorrhagic stroke in 17 patients (9 men and 8 women, aged 60.7 +/- 11.5 yr) and in 20 healthy controls (12 men and 8 women, aged 62.5 +/- 8.3 yr). Compared to controls, the plasma SOD and total superoxide scavenger activities (TSSA) were significantly lower and the NO levels were significantly higher among the stroke patients. XO showed a slight, nonsignificant increase in the patients, but the levels of MDA, NSSA, GRD, and GSH-Px did not show any significant differences between the two groups. The hemorrhage volume was negatively correlated with the initial score of the Glasgow Coma Scale and a positive correlation with lethal outcome, but it did not correlate significantly with any of the measured parameters. The results suggest that free radicals might play a role in the development of brain injury following brain hemorrhage.